This award will support studies that examine the impact of the proposed system alignment strategy on relevant measures of health and health equity, with a focus on understanding the strategy’s success or failure in dismantling forms of structural racism and inequity embedded within systems. This award will provide up to $500,000 in total funding to be used over a 36-month period to study the impact of the proposed system alignment approach on relevant measures of health and health equity. This award category is open only to applicants who have completed a pilot study of their proposed system alignment approach and can provide results that confirm the feasibility of the approach and its acceptability to key actors within the relevant medical, social, and public health systems. Applicants must provide documentation of pilot test results as part of their application, which may include a publication, report, working paper, or research brief. If the pilot test study was completed by an organization other than the applicant organization or a partnering organization, applicants must explain how their organization will ensure that it has the necessary knowledge, experience, community relationships, and trust to replicate the results of the pilot test.