Identifying the Causes of a Persistent Health Disparity: High Blood Pressure Among African-Americans
Jan 29, 2015, 7:31 AM, Posted by Jacquelyn Taylor
Jacquelyn Taylor, PhD, PNP-BC, RN, FAAN, is an associate professor of nursing at Yale University and an alumna of the Robert Wood Johnson Foundation (RWJF) Nurse Faculty Scholars program (2008-2012). She recently received a $3.4 million grant from the National Institute of Nursing Research, a department of the National Institutes of Health, to conduct a large-scale study on the influence of genetic and psychological factors on high blood pressure in African-American women and children.
Human Capital Blog: Congratulations on your new grant from the National Institutes of Health to study blood pressure in African-Americans. What will be your focus?
Jacquelyn Taylor: African-Americans have the highest incidence of hypertension of any racial or ethnic group in our country. Studies show that some medications don’t work very well in reducing blood pressure in this population, and we are convinced that some other underlying mechanisms are at play. My co-principal investigator, Cindy Crusto, PhD, an associate professor in the department of psychology at Yale School of Medicine, and our research team and I will be studying two of those—genetic markers and psychological factors, such as perceived feelings of racism, mental health, and parenting behaviors—in our study. We want to know what effects these variables have on increases in blood pressure among African-American women and children over time.
HCB: Does this study build on your earlier work?
Taylor: In a previous study in Detroit, I looked at gene-environment interactions for high blood pressure in three generations of African-American women and identified hypertension risk alleles in grandmothers and in their daughters and granddaughters. Then I replicated the study in West Africa, where people live the same way as they did in the 1400s—in clay huts, with no running water, no sanitation, and no fast food as in the developed areas such as Detroit. The West African Dogon sample were mostly underweight, participated in large amount of physical activity, and had a limited but healthy diet. But they still had the same genetic markers for hypertension that I had identified in the sample in Detroit.