This article describes efforts to use information on influenza burden and vaccine efficacy to estimate how influenza vaccine recommendations might impact children's influenza-related hospitalizations and outpatient visits. Researchers reviewed studies that provided information as to rates of vaccination per 1,000 children ages 6 to 23 months and 24 to 59 months. Vaccine efficacy was measured in 25 percent, 50 percent and 75 percent markers of how much vaccines corresponded with active strains of influenza.
- In order to avoid one influenza-related hospitalization, vaccinations would need to be given to an estimated 1,031 to 3,050 children ages 6 to 23 months and 4,255 to 6,897 children ages 24 to 59 months.
- The amount of children requiring influenza vaccination to avoid hospitalization decreased as vaccine efficacy and severity of influenza season increased.
- The amount of children that would require vaccination to avoid influenza-related hospitalization was estimated to be between 45-fold to more than 100-fold greater than the number required to be vaccinated to avoid an influenza-related outpatient visit.
- In order to avoid one influenza-related outpatient visit, vaccinations (with 50% vaccine efficacy) would need to be given to an estimated 12 to 42 children ages 6 to 59 months.