Newborn metabolic (heelstick) screening is a universally accepted public health activity that has been used for the past three decades. Although screening has a profound impact on the health of newborns, recent trends in diagnostic capability, technology, society, and the health care system raise new issues and challenges to providing this care. The American Academy of Pediatrics (AAP), at the request of the Health Services and Resources Administration (HRSA), created the National Task Force on Newborn Screening to outline a national agenda for strengthening state newborn screening programs. This task force recommended developing the public health infrastructure and integrating newborn screening systems with the health care delivery system in addition to establishing a national process to share and promote best practices in information integration models. In response, the Genetic Services Branch, Maternal and Child Health Bureau (GSB/MCHB) of HRSA contracted with the Center for Innovation in Health Information Systems to identify and describe best practices in integrating newborn screening information with other early childhood health information. Seven states actively in the planning process of integration initiatives were chosen for a two-day site visit. The report identifies key elements critical for the success of such integration as well as best practices in implementation. This "Sourcebook" contains relevant bibliographic resources for information systems program managers engaged in planning, developing or implementing an integrated child health information system.