Characteristics of Clinical Trials to Support Approval of Orphan vs Nonorphan Drugs for Cancer
June 8, 2011 | Journal Article
More stringent evaluation of orphan drug trials is recommended to ensure safety and efficacy.
Clinical Trials
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Examining the Evidence
July 1, 2011 | Journal Article
Older patients—the most complex and expensive patients—are not adequately represented in randomized controlled trials.
Designing Comparative Effectiveness Research on Prescription Drugs
October 1, 2010 | Journal Article
As comparative effectiveness research becomes a more prominent feature of clinical medicine, investigators and policy-makers would do well to seek lessons from prior examples of this type of research.
Massage Therapy Versus Simple Touch to Improve Pain and Mood in Patients with Advanced Cancer
September 16, 2008 | Journal Article
This study compares the use of massage therapy to relieve pain and other symptoms to simple touch therapy for terminally ill individuals.
Integration of Depression and Hypertension Treatment
July 1, 2008 | Journal Article
This article examines whether integrating depression treatment into care for hypertension improves adherence to antidepressant and antihypertensive medications, depression outcomes and blood pressure control among older primary care patients.
The ADVANTAGE Seeding Trial
August 19, 2008 | Journal Article
Seeding trials are clinical studies conducted by pharmaceutical companies designed to seem as if they answer a scientific question, but primarily fulfill marketing objectives they have not been described in detail.
Preventing Diabetes in the Clinical Setting
January 1, 2006 | Journal Article
Type 2 diabetes affects 8 percent of U.S. adults, as well as a growing number of youth. Increased prevalence of diabetes will cause a serious increase in early morbidity, health care costs and lost productivity. There is now substantial evidence tha ...