This article offers an in-depth review of studies on the clinical high-risk (HR) state for psychosis.

The high-risk (HR) construct has the potential to possibly alter the course of developing major psychotic disorders. Recently, the HR stage of psychosis is being considered as a new diagnostic category in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). This article provides a comprehensive state-of-the-art review, based on leading experts in the field. It draws from 20 years of literature, presenting illustrative figures and tables on progress in the field of prodromal psychosis. Worldwide experts reviewed PubMed, books, meetings, abstracts, and international conferences and core results are presented after consensus.

Key Finding:

  • In early detection of psychosis, a key goal is the delay or prevention of the psychotic onset. The new field of HR research in psychosis has the potential to aid in the treatment of individuals who are vulnerable to psychotic illness.

From the historical development, to the future challenges in the field, this comprehensive literature review highlights the progress that has been made. The importance of the HR state in psychotic disorders is increasingly gaining recognition, yet new challenges still leave room for further clinical study.