Higher levels of fibroglast growth factor 23 (FGF23) but lower levels of uncarboxylated matrix Gla protein (ucMGP), both regulators of mineral metabolism and inhibitors of vascular calcification, are associated with cardiovascular disease (CVD) events or death in outpatients who have stable coronary artery disease. A third protein, Fetuin-A, has no association.
It is known that abnormalities in mineral metabolism are associated with CVD risk in the general population. The three proteins at hand recently have been identified as regulators of arterial calcification but the relationship between these proteins and CVD events and mortality is unknown. This study recruited outpatients, with stable coronary artery disease, of San Francisco Bay area clinics between September 2000 and December 2002. The health of 833 participants was then tracked from their baseline examinations until December 2008.
The mechanisms for how these proteins impact the risks of CVD events and mortality is an avenue for further investigation. However, these study results may help identify persons at greater risk of CVD events and death and ultimately lead to prevention and treatments.