In 1999, the Oklahoma immunization registry, OSIIS, helped shape the CDC's Advisory Committee on Immunization Practices (ACIP) recommendation on the use of inactivated polio vaccine (IPV) rather than oral polio vaccine (OPV).
OSIIS data included a large set of immunization providers and a large proportion of the population. OSIIS was able to set up data queries to allow the analysis of the percentage of birth cohort receiving IPV versus OPV as first and second polio dose.
Data from the registry showed no delays and, in fact, demonstrated that children who received IPV as their first polio dose were more likely to be up-to-date. The analysis was instrumental in shaping the ACIP decision to adopt an all-IPV recommendation.