Thioredoxin reductase: A novel therapeutic target for latent parasites -- Rosa Mercedes Andrade, MD
The Foundation's Harold Amos Medical Faculty Development Program was designed to provide four-year postdoctoral research awards offered to historically disadvantaged physicians who are committed to developing careers in academic medicine, to improving the health of underserved populations, and to furthering the understanding and elimination of health disparities.This grant supports a research project with two major goals: (1) to prove that auranofin is a new anti-toxoplasma agent with the potential to affect tachyzoites and bradyzoites forms of Toxoplasma gondii; and (2) to demonstrate that auranofin's target is T.gondii thioredoxin reductase. These results will open a new research line for anti-parasitic drug development.
Amount Awarded $420,000.00
Awarded on: 12/17/2012
Time frame: 1/1/2013 - 1/31/2016
Grant Number: 70642