Tropism-modified conditionally replicative adenoviruses for aggressive meningiomas - Jerry Jeff Jaboin, MD, PhD
The Foundation's Harold Amos Medical Faculty Development Program was designed to provide four-year postdoctoral research awards offered to historically disadvantaged physicians who are committed to developing careers in academic medicine, to improving the health of underserved populations, and to furthering the understanding and elimination of health disparities.The grantee hypothesizes that conditionally replicative adenoviruses (CRAds) represent a viable and attractive targeted strategy for the treatment of aggressive meningiomas. The goal of this project is to construct a tropism-enhanced CRAd. He will utilize the Tissue Slice Method, a highly relevant tissue-based, pre-clinical technique to prioritize enhanced CRAd. Then it will be tested in three cross-functional and stringent in vivo models. He will use an orthotopic murine xenograft model of meningioma to evaluate liver: tumor binding. The Syrian golden hamster model will be employed to test the toxicity of the resultant infectivity-enhanced CRAd. He will also design a pseudogenotyped canine CRAd to evaluate the safety and efficacy in a large, mammal animal model.
Amount Awarded $420,000.00
Awarded on: 3/12/2013
Time frame: 7/1/2013 - 6/30/2017
Grant Number: 70641