Urinary-ammonium-excretion rate and the risk of chronic-kidney-disease progression -- Kalani Lukela Raphael, MD, MSCI
The Foundation's Harold Amos Medical Faculty Development Program was designed to provide four-year postdoctoral research awards offered to historically disadvantaged physicians who are committed to developing careers in academic medicine, to improving the health of underserved populations, and to furthering the understanding and elimination of health disparities.Renal ammoniagenesis and urinary ammonium excretion are normal physiological processes that are up-regulated in chronic kidney disease (CKD) to maintain acid-base balance. However, chronically up-regulated renal ammoniagenesis and urinary ammonium excretion cause further renal damage in animal models of CKD. Whether this is true in humans is uncertain. Therefore, the goal of this project is to test the hypothesis that urinary ammonium excretion rate, as a measure of renal ammoniagenesis, is a risk factor for CKD progression. As renal ammoniagenesis and urinary ammonium excretion are reduced by alkalinizing agents such as sodium bicarbonate, the results of these studies could lead to significant changes in how we assess, monitor, and intervene upon renal acid excretory mechanisms to improve renal outcomes in people with CKD.
Amount Awarded $420,000.00
Awarded on: 12/21/2012
Time frame: 1/1/2013 - 12/31/2016
Grant Number: 70643