Network analysis of genomic variation and gene expression associated with atrial fibrillation - Marco Valentin Perez, MD
The Foundation's Harold Amos Medical Faculty Development Program was designed to provide four-year postdoctoral research awards offered to historically disadvantaged physicians who are committed to developing careers in academic medicine, to improving the health of underserved populations, and to furthering the understanding and elimination of health disparities.Atrial fibrillation (A-FIB) is an arrhythmia characterized by disorganized electrical activity in the atrium leading to loss of effective myocardial contraction, affects over 2.2 million people in the US and is associated with an increased risk of stroke and death. Genome-wide association studies (GWAS) and gene expression studies have identified genes associated with A-FIB. This project will identify coding and non-coding RNA sequences associated with atrial fibrillation. Novel deep-sequencing technologies allow precise measurement of gene expression and exploration of information regarding alternative splicing and roles of intergenic RNA. The second aim is to find novel therapeutic targets in A-FIB pathways based on data from African American GWAS, myocardial gene expression experiments and semantic literature mining. Finally, the project will test the functional effects of newly identified targets on fundamental electrophyisiologic parameters that influence maintenance of atrial fibrillation.
Amount Awarded $420,000.00
Awarded on: 12/11/2012
Time frame: 1/1/2013 - 12/31/2016
Grant Number: 70637