Search Results for: antibiotic

Jun 4 2013

NIH-Funded Research to Explore Intractable Public Health Concerns

New funding by the National Institutes of Health (NIH) is aimed at improving treatment for bacterial infections, treating alcohol dependence and determining effective drugs for long-term diabetes treatment.

  • Antibiotic Resistance: Duke University has been awarded $2 million by the NIH for a clinical research network focused on antibacterial resistance. Funding could rise to close to $70 million by 2019. According to the NIH, bacterial infections resistant to antibiotic drugs were first reported more than 60 years ago and since then have become more common in both health care and community settings. In some cases, no effective antibiotics exist. The funding will be used to conduct clinical trials on new drugs, optimizing use of existing ones; testing diagnostics and conducting research on best practices for infection control.
  • Alcohol Dependence: A new study funded by the NIH and published in the Journal of Addiction Medicine finds that the smoking-cessation drug varenicline (brand name Chantix), significantly reduced alcohol consumption and craving among people who are alcohol-dependent. “Current medications for alcohol dependence are effective for some, but not all, patients. New medications are needed to provide effective therapy to a broader spectrum of alcohol dependent individuals,” said says Kenneth R. Warren, PhD, acting director of the National Institute on Alcohol Abuse and Alcoholism, part of NIH. Participants who took varenicline, compared with those taking a placebo, decreased their heavy drinking days per week by nearly 22 percent.  
  • Diabetes: The NIH is currently recruiting volunteers for a study to compare the long-term benefits and risks of four widely used diabetes drugs in combination with metformin, the most common first-line medication for treating type 2 diabetes. The study is important because if doctors find that metformin is not effective enough to help manage type 2 diabetes, they often add another drug to lower blood glucose levels. However, there have been no long-term studies on which of the add-on drugs are most effective and have fewest side effects. The study will compare drug effects on glucose levels, adverse effects, diabetes complications and quality of life over an average of nearly five years and will enroll about 5,000 patients at 37 study sites.
May 3 2013

Public Health News Roundup: May 3

CDC: Only 20 Percent of U.S. Adults Meet Aerobic, Muscle-strengthening Requirements
Only about one in five U.S. adults meet the aerobic and muscle strengthening components of the federal government's Physical Activity Guidelines for Americans, according to a new report in the U.S. Centers for Disease Control and Prevention’s (CDC) Morbidity and Mortality Weekly Report. The guidelines call for a minimum of 2.5 hours of moderate-intensity aerobic activity each week, or 1.25 hours of vigorous-intensity aerobic activity, as well as at least two days of muscle-strengthening activities. About half of adults meet the aerobic minimums and 30 percent meet the muscle-strengthening requirements, which Carmen D. Harris, MPH, epidemiologist in CDC's physical activity and health branch, called “encouraging.” "This is a great foundation to build upon, but there is still much work to do,” she said. “Improving access to safe and convenient places where people can be physically active can help make the active choice the easy choice." Read more on physical activity.

Hospital Programs Find Success in Cutting Antibiotic Prescriptions, Drug-resistant Bacteria
Hospital programs designed to decrease the number of prescriptions for antibiotics also successfully cut the number of drug-resistant bacteria, according to a new study in the Cochrane Library. Such bacteria, as well as the possibility of secondary infections, can leave patients especially at risk. "Antibiotic resistance is recognized worldwide as a public health problem that's just getting worse. Really around the world people are worried that we'll end up with bacteria that are resistant to the antibiotics we've got," said Peter Davey, MD, of the University of Dundee in Scotland. Researchers found that while persuasion/education programs were effective, actually restricting prescriptions saw more improved outcomes early on, which persuasion/education’s effectiveness catching up later. "We got good evidence that restrictive interventions work faster in terms of changing prescribing and microbial outcomes," he said. Read more on preventing antibiotic resistance.

Suicide Rate Up Significantly for Middle-aged Americans
Attempts to explain the dramatic increase in suicides by middle-aged Americans over the past decade have left many public health experts “dumfounded,” according to Lanny Berman, executive director of the American Association of Suicidology. "The best we can come up with is maybe this is the group most likely to be affected by the recession and unemployment and [home] foreclosure," he said. "It affected suicide rates both nationally and internationally." A new report from the U.S. Centers for Disease Control and Prevention reveals that suicides for people aged 35-64 rose by 28 percent from 1999 to 2010. For comparison’s sake, more Americans died by suicide in 2010 (38,364) than in car crashes (33,687). According to an agency news release: "Suicide is a tragedy that is far too common. The stories we hear of those who are impacted by suicide are very difficult. This report highlights the need to expand our knowledge of risk factors so we can build on prevention programs that prevent suicide,” said CDC Director Tom Frieden, MD. Read more on mental health.

Apr 30 2013

Extending the Cure Releases Antibiotic Resistance Research

In recent years many bacteria have become resistant to drugs that commonly vanquished them, depleting a natural resource—antibiotics—that has saved millions of lives around the globe. Using these drugs only when necessary, and using the right drug for the right infection will help ensure that the medications are available and effective when they’re needed.

>>Watch a new, three-minute animated video that tells the story of how antibiotic-resistant “superbug” bacteria have become a serious public health threat that affects everyone. The video frames the problem uniquely: We must treat antibiotics as a natural resource that can be depleted with overuse, just like water, trees, and other resources on which we all depend. The video lays out specific steps that everyone – including doctors, hospitals, and consumers – can take to tackle the problem.

Ramanan Laxminarayan Ramanan Laxminarayan, Extending the Cure

Extending the Cure (ETC), a project of the Center for Disease Dynamics, Economics & Policy based in Washington, D.C., and New Delhi, released the Superbugs video this week, along with a new report on trends in antibiotic resistance.

Last year, the organization also released research showing that certain types of bacteria responsible for causing urinary tract infections (UTIs) are becoming more difficult to treat with current antibiotics. ETC released the research via its online ResistanceMap, an online tool created to track changes in antibiotic drug use and resistance. A new, added feature of the ResistanceMap is ETC’s Drug Resistance Index, a way for non-experts to track changes in antibiotic effectiveness.

This research was funded by the Robert Wood Johnson Foundation. Urinary tract infections account for about 8.6 million visits to health care providers each year, according to the Centers for Disease Control and Prevention. More than half of U.S. women will get a UTI in their lifetime.

“Without proper antibiotic treatment, UTIs can turn into bloodstream infections, which are much more serious and can be life-threatening,” said Ramanan Laxminarayan, director of Extending the Cure (ETC). “These findings are especially disturbing because there are few new antibiotics to replace the ones that are becoming less effective,” says Laxminarayan. 

Read a previous NewPublicHealth interview with Ramanan Laxminarayan about ETC’s research and Drug Resistance Index.

Read more

Mar 13 2013

Public Health News Roundup: March 13

NIH: Cardiovascular Benefits Outweigh Small Weight Gain for Former Smokers
When it comes to health, the small amount of weight someone can gain after quitting smoking is inconsequential compared to the improvement in cardiovascular health, according to a new study in the Journal of the American Medical Association. Researchers from the National Institutes of Health found that current smokers were at twice the risk of developing cardiovascular disease as were former smokers without diabetes. “Our findings suggest that a modest weight gain, around 5-10 pounds, has a negligible effect on the net benefit of quitting smoking,” said study co-author Caroline Fox, MD, MPH, senior investigator in the Laboratory for Metabolic and Population Health at the NIH’s National Heart, Lung, and Blood Institute (NHLBI). “Being able to quantify to some degree the relationship between the benefits and side effects of smoking cessation can help in counseling those who have quit or are thinking about quitting.” Read more on tobacco.

FDA: Antibiotic Azithromycin Can Cause Fatal Irregular Heart Rhythm
The antibiotic azithromycin, also known as Zithromax, can lead to a potentially fatal irregular heart rhythm by changing the heart’s electrical activity, the U.S. Food and Drug Administration (FDA) has warned. The FDA is cautioning physicians to be wary of certain risk factors when prescribing the antibiotic, including low levels of potassium or magnesium, a slower-than-normal heart rate and the presence or other drugs to treat abnormal heart rhythms. Read more on heart health.

Study: Breast-feeding has No Effect on Weight Later in Life
Despite previous studies suggesting a possible link, breast-feeding does not reduce the chances that a child will grow up to be overweight or obese, according to a new study in the Journal of the American Medical Association. Still, breast-feeding does bring several health benefits, including a reduced risk of gastrointestinal and respiratory infections; a higher IQ; and lower incidence of eczema. It also reduces the risk of breast and ovarian cancer in the mother. "Although breast-feeding is unlikely to stem the current obesity epidemic, its other advantages are amply sufficient to justify continued public health efforts to promote, protect and support it," said the study's lead author, Richard Martin, a professor of clinical epidemiology at the University of Bristol in England. Read more on infant and maternal health.

Nov 20 2012

Public Health News Roundup: November 20

Study: Medicare Patients More Likely to Have Repeated Tests
Older adults on Medicare are more likely to have heart, lung, stomach or bladder tests repeated within three years, according to a new study in the Archives of Internal Medicine. "What we were struck by is just how commonly these tests are being repeated," said H. Gilbert Welch, MD, from the Dartmouth Institute for Health Policy and Clinical Practice in Hanover, New Hampshire. "Either these patients continually develop new problems or there are doctors who routinely repeat tests." Excessive testing can lead to unnecessary costs and treatments, Welch said. Read more on access to health care.

Use of Discontinued Meds Shows Need for Electronic Updates to Pharmacies
Even though the treatments are complete, some pharmacists continue to fill prescriptions for patients, which can unintentionally cause health issues ranging from nausea or lightheadedness to low blood pressure or allergic reactions, according to a study in the Annals of Internal Medicine. Researchers found that about 12 percent of discontinued medications caused harm, which demonstrates the need to electronically alert pharmacies when a medication is prescription is discontinued, said Adrienne Allen, MD, associate medical director of quality, safety and risk at the Boston-area North Shore Physicians Group."Future research should focus on evaluating methods of improving communication between providers and pharmacies to better reconcile medication lists, as well as explore strategies to improve patient knowledge and awareness of their medication regimen." Read more on prescription drugs.

Link Between Antibiotic Use During Pregnancy, Asthma in Children
Antibiotic use during pregnancy increases the chance that a child will have asthma, according to a new study in The Journal of Pediatrics. Researchers concluded the children were 17 percent more likely to be hospitalized for the breathing disorder. "We speculate that mothers' use of antibiotics changes the balance of natural bacteria, which is transmitted to the newborn, and that such unbalanced bacteria in early life impact on the immune maturation in the newborn," said Hans Bisgaard, MD, a professor at the University of Copenhagen. The findings support previous research linking antibiotics to asthma. Read more on maternal and infant health.

Sep 25 2012

Public Health News Roundup: September 25

Health Insurers Now Providing User-friendly Benefit Guides
Starting this week, health insurers will provide patients with user-friendly guides that clearly explain their benefits. The goal of the new law is to enable “the private insurance market's 163 million beneficiaries to make side-by-side comparisons of plan offerings,” according to Reuters. The U.S. Department of Health and Human Services released a sample benefits form demonstrating the new standardized format. Read more on access to health care.

Inconsistencies in Antibiotic Prescriptions Could Contribute to Increased Resistance
Inconsistencies in how U.S. seniors are prescribed antibiotics could be contributing to increased bacterial resistance, according to a report in the Archives of Internal Medicine. The information was compiled from Medicare records. Seniors in some areas of the country average less than one prescription a year, while others averaged between one and two, suggesting overuse in some areas. "Once you get resistance to those broad spectrum antibiotics, next time you have anything where you really need that, it's not going to be as effective," said Yuting Zhang, the study's lead author. Read more on bacteria.

Task Force Recommends Screening, Intervention to Combat Alcohol Abuse
The U.S. Preventive Services Task Force has recommended that doctors make questions about drinking habits a part of routine patient visits. It is also recommending they provide alcohol abuse counseling. The task force found screening and intervention to be effective public health tactics in adults ages 18 and older. The new recommendations are in line with the task force’s 2004 guidelines, according to HealthDay. "The overarching message is the same as it was back then,” said Michael LeFevre, MD, co-vice chair for the task force. “At least in the adult population, the evidence shows that clinicians can help men and women who are drinking in ways that are not healthy to change those habits." Read more on alcohol.

Aug 27 2012

What Happens When the NIH Has Little in its Arsenal to Treat a Lethal Bacterial Outbreak?

Researchers at the National Institutes of Health published a journal article  last week  in Science Translational Medicine about how they used genetic testing to determine the source of a bacterial infection, Klebsiella pneumoniae, that killed eleven patients and is highly resistant to antibiotics. To treat the patient they believe initiated the outbreak, who had been transferred from another state but who had the infection when she entered the hospital, doctors used an old antibiotic, colistin, which is rarely used because it can damage kidneys. And to stem the spread, the hospital restored to extreme measures including tearing out plumbing that harbored the infection and regularly testing every patient in the hospital for the infection. The measures worked, but a recent article in the Washington Post highlights reasons why there are so few new antibiotics with reach to treat “superbugs” including a growing lack of interest among pharmaceutical firms because other drugs make more money.

>>Bonus Link: Read a NewPublicHealth post about an antibiotic resistance study by researchers at Extending the Cure, which is funded by the Robert Wood Johnson Foundation. The study found that in the winter time, flu symptoms boost both antibiotic use and resistance.

Aug 22 2012

Public Health News Roundup: August 22

AHA Identifies Most-Effective Public Health Strategies
American Heart Association researchers have examined more than 1,000 scientific studies to determine 43 of the most effective public health prevention strategies. They include school and workplace interventions; economic incentives to improve access to healthy food; direct mandates and restrictions related to nutrition; local environment efforts; and media and education campaigns. The findings were published in Circulation, an American Heart Association journal. “Policy-makers should now gather together and say, ‘These are the things that work—let’s implement many right away, and the rest as soon as possible,’” said Dariush Mozaffarian, MD, DrPH, chair of the statement writing group. Read more on heart health.

Poor Dental Health May Be Factor in Dementia
A new study in the Journal of the American Geriatrics Society shows a link between poor dental health and a greater risk of dementia. The study looked at the number of natural teeth, dentures worn, the number of visits to a dentist and other general oral health habits of 5,486 adults with the median age of 81 between the years of 1992 and 2010. The link was especially significant in men. A 2011 report from the Institute of Medicine of the National Academies, Improving Access to Oral Health Care for Vulnerable and Underserved Populations, stressed the importance of providing good oral health care to vulnerable and underserved populations. Read more on aging.

New Federal Report on the Health, Economic Status of Older Americans
While today’s older Americans are healthier and living longer than those of past generations, increased financial obligations and the rising obesity rate are still major considerations, according to Older Americans 2012: Key Indicators of Well-Being, a new report from the National Institutes of Health. The report looks at 37 key indicators to determine which areas are—and are not—improving for older Americans. By 1930 there will be approximately 72 million Americans age 65 and older, according to the Federal Interagency Forum on Aging-Related Statistics. Read more on older adults.

NYU Study Finds Antibiotic Use in Very Young May Increase Childhood Weight
Infants who received antibiotics before the age of 6 months are more likely to be overweight, according to a new study of more than 10,000 children. The study was published August 21 in the International Journal of Obesity and conducted by the NYU School of Medicine and the NYU Wagner School of Public Service. The researchers were careful to note that the study merely showed a correlation—not causation—and that more study is needed. “We typically consider obesity an epidemic grounded in unhealthy diet and exercise, yet increasingly studies suggest it’s more complicated,” said Leonardo Trasande, MD, MPP, an associate professor of pediatrics and environmental medicine at the NYU School of Medicine. “Microbes in our intestines may play critical roles in how we absorb calories, and exposure to antibiotics, especially early in life, may kill off healthy bacteria that influence how we absorb nutrients into our bodies, and would otherwise keep us lean.” Read more on infant health.

Aug 10 2012

Public Health News Roundup: August 10

CDC Recommends Against Using Popular Gonorrhea Treatment
Infectious disease experts at the Centers for Disease Control and Prevention recommended this week that the antibiotic Suprax (cefixime) no longer be used to treat gonorrhea. The CDC is discouraging use of Suprax because patients are developing resistance to the drug. As first line treatment, the CDC recommends use of the drug ceftriaxone in combination with azithromycin or doxycycline. Read more on sexual health.

Alcohol Ad Violations More Common in Magazines with High Youth Readership
As the youth readership level of a magazine goes up, so too does the likelihood that alcohol advertisements in the publication are in violation of industry standards, according to a new study. The study was conducted by the Center on Alcohol Marketing and Youth (CAMY) at the Johns Hopkins Bloomberg School of Public Health and published in the Journal of Adolescent Health. The study looked at 1,261 advertisements for alcopops, beer, spirits or wine that appeared more than 2,500 times in 11 different with youth readership levels of at least 15 percent. CAMY Director and study co-author David Jernigan, PhD said the findings indicate the industry standards should be strengthened. Read more on alcohol.

SAMHSA Awards $11M to Treat Substance Abuse in Pregnant and Postpartum Women
The Substance Abuse and Mental Health Services Administration (SAMHSA) has awarded up to $11 million in grants under the Service Grants Program for the Residential Treatment for Pregnant and Postpartum Women (PPW). There are seven total grants to be utilized over the next three years. They will go toward improving substance abuse treatment, prevention and recovery support services for pregnant women, new mothers and their minor children. “This program offers vital help and hope to women at a crucial time in their lives and in the lives of their children,” said SAMHSA Administrator Pamela S. Hyde in a release. “By including families in the supportive services that are being provided for these women, we acknowledge that people with substance use disorders are more than just their addictions.” Read more on substance abuse.

Aug 7 2012

Study: Flu Symptoms Boost Antibiotic Use, Antibiotic Resistance During Winter Months

Although a June study in Pediatrics noted a recent drop in antibiotics prescribed for infants, children and adolescents relative to past years, prescriptions continue to be high in winter months and may lead to increased antibiotic resistance, according to a new study in Clinical Infectious Diseases.  Research on the link between flu and a rise in antibiotic prescribing in the winter was conducted by Extending the Cure, which is funded by the Robert Wood Johnson Foundation Pioneer Portfolio, to research and examine solutions to antibiotic resistance.

The Clinical Infectious Diseases study found that increases in prescription sales for two popular groups of antibiotics during flu season led to a rapid increase, one month later, in resistant Escherichia coli (E. coli) in hospitals, as well as a rise in methicillin-resistant Staphylococcus aureas (MRSA), linked to the seasonal increase in antibiotic prescriptions.

In a recent op-ed published in Modern Healthcare, Ramanan Laxminarayan, study author and director of Extending the Cure, offered recommendations to help decease use of antibiotics and antibiotic resistance, such as giving all healthy people age 6 months and up the flu shot—because if fewer people experience flu symptoms, fewer people will receive unnecessary antibiotic prescriptions.

“It’s time to start viewing antibiotics as a natural resource that can be depleted with overuse, much like oil or other natural resources, and which must be conserved so these resources are there for us when we need them,” says Laxminarayan.

>>Read a related Q&A with Ramanan Laxminarayan, executive director of Extending the Cure, where he talks about the need for a shift in social norms around parents asking for antibiotics for their children when it may not be needed.

>>Bonus Link:  Read a policy brief from Extending the Cure about strategies to reduce doctor’s over-prescribing of antibiotics including education programs, incentives and mandating appropriate prescribing.  

>>New Study:  A new study in the Annals of Internal Medicine finds that adding data on circulating infections to electronic health records helps reduce antibiotic overuse by giving doctors real-time data to inform diagnosis on viral or bacterial infections.