Search Results for: antibiotic
Study: 40 Percent of Antibiotics Released from 1980-2009 Withdrawn from Market
Safety concerns, lack of effectiveness when compared to existing drugs and weak sales led more than 40 percent of the antibiotics released between 1980 and 2009 to be withdrawn from the market, according to a new study in the Journal of Law, Medicine and Ethics. The rate was three times as high as that for any other type of drug. “This study raises the question whether or not money would be better spent on higher quality antibiotics, rather than a larger quantity” and whether “approving a flood of new lower-quality antibiotics might actually trigger much higher levels of resistance,” said author Kevin Outterson, JD, LLM, professor at Boston University School of Law and co-director of the Boston University Health Law Program. Antibiotic use can lead to bacteria becoming resistant to a strain. A recent report from the U.S. Centers for Disease Control and Prevention found that as many as 50 percent of prescriptions for antibiotics are either not needed or prescribed inappropriately. Antibiotic-resistant infections sicken more than two million Americans each year, killing more than 23,000 in the process. Read more on prescription drugs.
Locations of Drinking Can Influence Types of Partner Violence
Where and when a person drinks can affect the type of partner violence that can follow, according to a new study from the journal Addiction. The study looked at six drinking locations: restaurants, bars, parties at someone else's home, quiet evenings at home, with friends in one's own home and in parks/other public places. Researchers from the Prevention Research Center in California and Arizona State University found that men drinking in bars and at partners away from home and women drinking in parks/other public places were linked with an increased rate of male-to-female violence. They also found that men drinking during quiet evenings at home was associated with increased female-to-male violence. The findings could help prevent partner violence by encouraging people in risky relationships not to drink in particular places/situations, which could prove more effective than counseling people simply to drink less. Read more on alcohol.
Multiple Myeloma Group Hopes Opening Records to Hundreds of Patients Will Advance Research
The Multiple Myeloma Research Foundation's (MMRF) Researcher Gateway is opening global online access to genetic and research data on hundreds of patients in an effort to help identify biological targets for future treatments, improve enrollment in studies by pairing them with the right patients and enhance researcher collaboration. The MMRF Research Gateway is a $40-million program funding by the foundation and drug company partners. The main component of the effort will be the Commpass study which will enroll 1,000 new multiple myeloma patients and monitor them throughout the course of the disease; cancer tissue banks typically include only one sample per patient. "There is going to be new information generated there that you would never get unless you followed patients through first relapse and second relapse and beyond," said George Mulligan, director of translational medicine for Millennium Pharmaceuticals, Japan's Takeda Pharmaceutical Co.’s oncology unit, which is one of the co-sponsors. "The size of it in patient numbers and the breadth and richness of it on a biological level, it's going to grow over time and mushroom into something that's going to be really special.” About 86,000 people are diagnosed with multiple myeloma each year, with about 20,000 of those from the United States. Read more on research.
Antibiotic-resistant Infections on the Rise; Threat Called "Urgent"
Antibiotic-resistant infections sicken more than two million Americans each year, killing more than 23,000 in the process, according to a new study from the U.S. Centers for Disease Control and Prevention (CDC). The report ranked the threats according to seven factors, including health impact, economic impact, how common the infection is and how easily it is spread. It classified carbapenem-resistant Enterobacteriaceae (CRE), drug-resistant gonorrhea, and Clostridium difficile as “urgent." C. difficile alone causes about 250,000 hospitalizations and at least 14,000 deaths each year. Excessive antibiotic use is the number one cause of the increase in antibiotic-resistant infections, with as many as 50 percent of prescriptions either not needed or prescribed inappropriately. “Every time antibiotics are used in any setting, bacteria evolve by developing resistance. This process can happen with alarming speed,” said Steve Solomon, MD, director of CDC’s Office of Antimicrobial Resistance. “These drugs are a precious, limited resource—the more we use antibiotics today, the less likely we are to have effective antibiotics tomorrow.” Antibiotic-resistant infections also add as much as $20 billion in excess direct health care costs and account for as much as $35 billion in lost economic productivity. Read more on prescription drugs.
Survey: Nearly 80 Percent of College Students Oppose Concealed Handguns on Campus
Nearly 80 percent of the students in 15 Midwestern colleges and universities oppose allowing concealed handguns on their campuses, according to a new study in the Journal of American College Health. Ball State University researchers surveyed 1,649 undergraduate students, finding 78 percent were against the handguns and would not apply for a permit if they were legal. “Firearm morbidity and mortality are major public health problems that significantly impact our society,” said study co-author Jagdish Khubchandani, a member of Ball State’s Global Health Institute and a community health education professor in the university's Department of Physiology and Health Science. “The issue of allowing people to carry concealed weapons at universities and colleges around the U.S. has been raised several times in recent years. This is in spite of the fact that almost four of every five students are not in favor of allowing guns on campus.”
The study also found that:
- About 16 percent of undergraduate students own a firearm and 20 percent witnessed a crime on their campus that involved firearms
- About 79 percent of students would not feel safe if faculty, students and visitors carried concealed handguns on campus
- About 66 percent did not feel that carrying a gun would make them less likely to be troubled by others
- Most students also believed that allowing concealed carry guns would increase the rate of fatal suicides and homicides on campus
Read more on violence.
‘Bath Salts’ Drugs Led to 23,000 ER Visits in 2011
The use of “bath salts” drugs accounted for almost 23,000 emergency department visits in the United States in 2011, according to a new report from the U.S. Substance Abuse and Mental Health Services Administration (SAMHSA). The report is the first national study to analyze the link between the street drugs and emergency department visits. "Although bath salts drugs are sometimes claimed to be 'legal highs' or are promoted with labels to mask their real purpose, they can be extremely dangerous when used," said Elinore McCance-Katz, MD, SAMHSA's chief medical officer. The drugs can cause heart problems, high blood pressure, seizures, addiction, suicidal thoughts, psychosis and even death. About two-thirds of the visits also involved at least one other drug, with 15 percent of the visits also being linked to marijuana or synthetic forms of marijuana. There were approximately 2.5 million U.S. emergency department visits linked to drug misuse or abuse in 2011. Read more on substance abuse.
New funding by the National Institutes of Health (NIH) is aimed at improving treatment for bacterial infections, treating alcohol dependence and determining effective drugs for long-term diabetes treatment.
- Antibiotic Resistance: Duke University has been awarded $2 million by the NIH for a clinical research network focused on antibacterial resistance. Funding could rise to close to $70 million by 2019. According to the NIH, bacterial infections resistant to antibiotic drugs were first reported more than 60 years ago and since then have become more common in both health care and community settings. In some cases, no effective antibiotics exist. The funding will be used to conduct clinical trials on new drugs, optimizing use of existing ones; testing diagnostics and conducting research on best practices for infection control.
- Alcohol Dependence: A new study funded by the NIH and published in the Journal of Addiction Medicine finds that the smoking-cessation drug varenicline (brand name Chantix), significantly reduced alcohol consumption and craving among people who are alcohol-dependent. “Current medications for alcohol dependence are effective for some, but not all, patients. New medications are needed to provide effective therapy to a broader spectrum of alcohol dependent individuals,” said says Kenneth R. Warren, PhD, acting director of the National Institute on Alcohol Abuse and Alcoholism, part of NIH. Participants who took varenicline, compared with those taking a placebo, decreased their heavy drinking days per week by nearly 22 percent.
- Diabetes: The NIH is currently recruiting volunteers for a study to compare the long-term benefits and risks of four widely used diabetes drugs in combination with metformin, the most common first-line medication for treating type 2 diabetes. The study is important because if doctors find that metformin is not effective enough to help manage type 2 diabetes, they often add another drug to lower blood glucose levels. However, there have been no long-term studies on which of the add-on drugs are most effective and have fewest side effects. The study will compare drug effects on glucose levels, adverse effects, diabetes complications and quality of life over an average of nearly five years and will enroll about 5,000 patients at 37 study sites.
CDC: Only 20 Percent of U.S. Adults Meet Aerobic, Muscle-strengthening Requirements
Only about one in five U.S. adults meet the aerobic and muscle strengthening components of the federal government's Physical Activity Guidelines for Americans, according to a new report in the U.S. Centers for Disease Control and Prevention’s (CDC) Morbidity and Mortality Weekly Report. The guidelines call for a minimum of 2.5 hours of moderate-intensity aerobic activity each week, or 1.25 hours of vigorous-intensity aerobic activity, as well as at least two days of muscle-strengthening activities. About half of adults meet the aerobic minimums and 30 percent meet the muscle-strengthening requirements, which Carmen D. Harris, MPH, epidemiologist in CDC's physical activity and health branch, called “encouraging.” "This is a great foundation to build upon, but there is still much work to do,” she said. “Improving access to safe and convenient places where people can be physically active can help make the active choice the easy choice." Read more on physical activity.
Hospital Programs Find Success in Cutting Antibiotic Prescriptions, Drug-resistant Bacteria
Hospital programs designed to decrease the number of prescriptions for antibiotics also successfully cut the number of drug-resistant bacteria, according to a new study in the Cochrane Library. Such bacteria, as well as the possibility of secondary infections, can leave patients especially at risk. "Antibiotic resistance is recognized worldwide as a public health problem that's just getting worse. Really around the world people are worried that we'll end up with bacteria that are resistant to the antibiotics we've got," said Peter Davey, MD, of the University of Dundee in Scotland. Researchers found that while persuasion/education programs were effective, actually restricting prescriptions saw more improved outcomes early on, which persuasion/education’s effectiveness catching up later. "We got good evidence that restrictive interventions work faster in terms of changing prescribing and microbial outcomes," he said. Read more on preventing antibiotic resistance.
Suicide Rate Up Significantly for Middle-aged Americans
Attempts to explain the dramatic increase in suicides by middle-aged Americans over the past decade have left many public health experts “dumfounded,” according to Lanny Berman, executive director of the American Association of Suicidology. "The best we can come up with is maybe this is the group most likely to be affected by the recession and unemployment and [home] foreclosure," he said. "It affected suicide rates both nationally and internationally." A new report from the U.S. Centers for Disease Control and Prevention reveals that suicides for people aged 35-64 rose by 28 percent from 1999 to 2010. For comparison’s sake, more Americans died by suicide in 2010 (38,364) than in car crashes (33,687). According to an agency news release: "Suicide is a tragedy that is far too common. The stories we hear of those who are impacted by suicide are very difficult. This report highlights the need to expand our knowledge of risk factors so we can build on prevention programs that prevent suicide,” said CDC Director Tom Frieden, MD. Read more on mental health.
In recent years many bacteria have become resistant to drugs that commonly vanquished them, depleting a natural resource—antibiotics—that has saved millions of lives around the globe. Using these drugs only when necessary, and using the right drug for the right infection will help ensure that the medications are available and effective when they’re needed.
>>Watch a new, three-minute animated video that tells the story of how antibiotic-resistant “superbug” bacteria have become a serious public health threat that affects everyone. The video frames the problem uniquely: We must treat antibiotics as a natural resource that can be depleted with overuse, just like water, trees, and other resources on which we all depend. The video lays out specific steps that everyone – including doctors, hospitals, and consumers – can take to tackle the problem.
Extending the Cure (ETC), a project of the Center for Disease Dynamics, Economics & Policy based in Washington, D.C., and New Delhi, released the Superbugs video this week, along with a new report on trends in antibiotic resistance.
Last year, the organization also released research showing that certain types of bacteria responsible for causing urinary tract infections (UTIs) are becoming more difficult to treat with current antibiotics. ETC released the research via its online ResistanceMap, an online tool created to track changes in antibiotic drug use and resistance. A new, added feature of the ResistanceMap is ETC’s Drug Resistance Index, a way for non-experts to track changes in antibiotic effectiveness.
This research was funded by the Robert Wood Johnson Foundation. Urinary tract infections account for about 8.6 million visits to health care providers each year, according to the Centers for Disease Control and Prevention. More than half of U.S. women will get a UTI in their lifetime.
“Without proper antibiotic treatment, UTIs can turn into bloodstream infections, which are much more serious and can be life-threatening,” said Ramanan Laxminarayan, director of Extending the Cure (ETC). “These findings are especially disturbing because there are few new antibiotics to replace the ones that are becoming less effective,” says Laxminarayan.
Read a previous NewPublicHealth interview with Ramanan Laxminarayan about ETC’s research and Drug Resistance Index.
NIH: Cardiovascular Benefits Outweigh Small Weight Gain for Former Smokers
When it comes to health, the small amount of weight someone can gain after quitting smoking is inconsequential compared to the improvement in cardiovascular health, according to a new study in the Journal of the American Medical Association. Researchers from the National Institutes of Health found that current smokers were at twice the risk of developing cardiovascular disease as were former smokers without diabetes. “Our findings suggest that a modest weight gain, around 5-10 pounds, has a negligible effect on the net benefit of quitting smoking,” said study co-author Caroline Fox, MD, MPH, senior investigator in the Laboratory for Metabolic and Population Health at the NIH’s National Heart, Lung, and Blood Institute (NHLBI). “Being able to quantify to some degree the relationship between the benefits and side effects of smoking cessation can help in counseling those who have quit or are thinking about quitting.” Read more on tobacco.
FDA: Antibiotic Azithromycin Can Cause Fatal Irregular Heart Rhythm
The antibiotic azithromycin, also known as Zithromax, can lead to a potentially fatal irregular heart rhythm by changing the heart’s electrical activity, the U.S. Food and Drug Administration (FDA) has warned. The FDA is cautioning physicians to be wary of certain risk factors when prescribing the antibiotic, including low levels of potassium or magnesium, a slower-than-normal heart rate and the presence or other drugs to treat abnormal heart rhythms. Read more on heart health.
Study: Breast-feeding has No Effect on Weight Later in Life
Despite previous studies suggesting a possible link, breast-feeding does not reduce the chances that a child will grow up to be overweight or obese, according to a new study in the Journal of the American Medical Association. Still, breast-feeding does bring several health benefits, including a reduced risk of gastrointestinal and respiratory infections; a higher IQ; and lower incidence of eczema. It also reduces the risk of breast and ovarian cancer in the mother. "Although breast-feeding is unlikely to stem the current obesity epidemic, its other advantages are amply sufficient to justify continued public health efforts to promote, protect and support it," said the study's lead author, Richard Martin, a professor of clinical epidemiology at the University of Bristol in England. Read more on infant and maternal health.
Study: Medicare Patients More Likely to Have Repeated Tests
Older adults on Medicare are more likely to have heart, lung, stomach or bladder tests repeated within three years, according to a new study in the Archives of Internal Medicine. "What we were struck by is just how commonly these tests are being repeated," said H. Gilbert Welch, MD, from the Dartmouth Institute for Health Policy and Clinical Practice in Hanover, New Hampshire. "Either these patients continually develop new problems or there are doctors who routinely repeat tests." Excessive testing can lead to unnecessary costs and treatments, Welch said. Read more on access to health care.
Use of Discontinued Meds Shows Need for Electronic Updates to Pharmacies
Even though the treatments are complete, some pharmacists continue to fill prescriptions for patients, which can unintentionally cause health issues ranging from nausea or lightheadedness to low blood pressure or allergic reactions, according to a study in the Annals of Internal Medicine. Researchers found that about 12 percent of discontinued medications caused harm, which demonstrates the need to electronically alert pharmacies when a medication is prescription is discontinued, said Adrienne Allen, MD, associate medical director of quality, safety and risk at the Boston-area North Shore Physicians Group."Future research should focus on evaluating methods of improving communication between providers and pharmacies to better reconcile medication lists, as well as explore strategies to improve patient knowledge and awareness of their medication regimen." Read more on prescription drugs.
Link Between Antibiotic Use During Pregnancy, Asthma in Children
Antibiotic use during pregnancy increases the chance that a child will have asthma, according to a new study in The Journal of Pediatrics. Researchers concluded the children were 17 percent more likely to be hospitalized for the breathing disorder. "We speculate that mothers' use of antibiotics changes the balance of natural bacteria, which is transmitted to the newborn, and that such unbalanced bacteria in early life impact on the immune maturation in the newborn," said Hans Bisgaard, MD, a professor at the University of Copenhagen. The findings support previous research linking antibiotics to asthma. Read more on maternal and infant health.
Health Insurers Now Providing User-friendly Benefit Guides
Starting this week, health insurers will provide patients with user-friendly guides that clearly explain their benefits. The goal of the new law is to enable “the private insurance market's 163 million beneficiaries to make side-by-side comparisons of plan offerings,” according to Reuters. The U.S. Department of Health and Human Services released a sample benefits form demonstrating the new standardized format. Read more on access to health care.
Inconsistencies in Antibiotic Prescriptions Could Contribute to Increased Resistance
Inconsistencies in how U.S. seniors are prescribed antibiotics could be contributing to increased bacterial resistance, according to a report in the Archives of Internal Medicine. The information was compiled from Medicare records. Seniors in some areas of the country average less than one prescription a year, while others averaged between one and two, suggesting overuse in some areas. "Once you get resistance to those broad spectrum antibiotics, next time you have anything where you really need that, it's not going to be as effective," said Yuting Zhang, the study's lead author. Read more on bacteria.
Task Force Recommends Screening, Intervention to Combat Alcohol Abuse
The U.S. Preventive Services Task Force has recommended that doctors make questions about drinking habits a part of routine patient visits. It is also recommending they provide alcohol abuse counseling. The task force found screening and intervention to be effective public health tactics in adults ages 18 and older. The new recommendations are in line with the task force’s 2004 guidelines, according to HealthDay. "The overarching message is the same as it was back then,” said Michael LeFevre, MD, co-vice chair for the task force. “At least in the adult population, the evidence shows that clinicians can help men and women who are drinking in ways that are not healthy to change those habits." Read more on alcohol.
Researchers at the National Institutes of Health published a journal article last week in Science Translational Medicine about how they used genetic testing to determine the source of a bacterial infection, Klebsiella pneumoniae, that killed eleven patients and is highly resistant to antibiotics. To treat the patient they believe initiated the outbreak, who had been transferred from another state but who had the infection when she entered the hospital, doctors used an old antibiotic, colistin, which is rarely used because it can damage kidneys. And to stem the spread, the hospital restored to extreme measures including tearing out plumbing that harbored the infection and regularly testing every patient in the hospital for the infection. The measures worked, but a recent article in the Washington Post highlights reasons why there are so few new antibiotics with reach to treat “superbugs” including a growing lack of interest among pharmaceutical firms because other drugs make more money.
>>Bonus Link: Read a NewPublicHealth post about an antibiotic resistance study by researchers at Extending the Cure, which is funded by the Robert Wood Johnson Foundation. The study found that in the winter time, flu symptoms boost both antibiotic use and resistance.
AHA Identifies Most-Effective Public Health Strategies
American Heart Association researchers have examined more than 1,000 scientific studies to determine 43 of the most effective public health prevention strategies. They include school and workplace interventions; economic incentives to improve access to healthy food; direct mandates and restrictions related to nutrition; local environment efforts; and media and education campaigns. The findings were published in Circulation, an American Heart Association journal. “Policy-makers should now gather together and say, ‘These are the things that work—let’s implement many right away, and the rest as soon as possible,’” said Dariush Mozaffarian, MD, DrPH, chair of the statement writing group. Read more on heart health.
Poor Dental Health May Be Factor in Dementia
A new study in the Journal of the American Geriatrics Society shows a link between poor dental health and a greater risk of dementia. The study looked at the number of natural teeth, dentures worn, the number of visits to a dentist and other general oral health habits of 5,486 adults with the median age of 81 between the years of 1992 and 2010. The link was especially significant in men. A 2011 report from the Institute of Medicine of the National Academies, Improving Access to Oral Health Care for Vulnerable and Underserved Populations, stressed the importance of providing good oral health care to vulnerable and underserved populations. Read more on aging.
New Federal Report on the Health, Economic Status of Older Americans
While today’s older Americans are healthier and living longer than those of past generations, increased financial obligations and the rising obesity rate are still major considerations, according to Older Americans 2012: Key Indicators of Well-Being, a new report from the National Institutes of Health. The report looks at 37 key indicators to determine which areas are—and are not—improving for older Americans. By 1930 there will be approximately 72 million Americans age 65 and older, according to the Federal Interagency Forum on Aging-Related Statistics. Read more on older adults.
NYU Study Finds Antibiotic Use in Very Young May Increase Childhood Weight
Infants who received antibiotics before the age of 6 months are more likely to be overweight, according to a new study of more than 10,000 children. The study was published August 21 in the International Journal of Obesity and conducted by the NYU School of Medicine and the NYU Wagner School of Public Service. The researchers were careful to note that the study merely showed a correlation—not causation—and that more study is needed. “We typically consider obesity an epidemic grounded in unhealthy diet and exercise, yet increasingly studies suggest it’s more complicated,” said Leonardo Trasande, MD, MPP, an associate professor of pediatrics and environmental medicine at the NYU School of Medicine. “Microbes in our intestines may play critical roles in how we absorb calories, and exposure to antibiotics, especially early in life, may kill off healthy bacteria that influence how we absorb nutrients into our bodies, and would otherwise keep us lean.” Read more on infant health.