Category Archives: Aging
NIH Spearheads Private/Public Collaboration to Improve Care for Several Serious Health Conditions, Including Alzheimer’s
The U.S. Department of Health and Human Services (HHS) today released the 2014 update for the National Plan to Address Alzheimer’s Disease, which includes a determination to accelerate efforts to identify the earliest stages of Alzheimer’s disease and to develop and test targets for intervention. That acceleration has new momentum this year with the announcement several weeks ago by the National Institutes of Health (NIH) that it has formed a first-if-its-kind partnership—the Accelerated Medicines Partnership (AMP) with ten pharmaceutical companies and several nonprofit organizations—to help identify and validate new diagnostics and drugs for several diseases that impact tens of millions of Americans and their families. The three other conditions are Type II diabetes, lupus and rheumatoid arthritis.
“Despite the fact that there have been huge revolutions in science from discovery of the double-helical structure of DNA, to recombinant DNA, to all sorts of interesting technological advances...it still takes too long and costs too much and we fail too often in the development of new drugs,” said Kathy Hudson, PHD, deputy director for Science, Outreach and Policy at the NIH, in a conversation with NewPublicHealth.
Hudson said a key development that drove the creation of the AMP is a new center at NIH, the National Center for Advancing Translational Sciences, which she says will work on how to “create new methods and new approaches that will decrease the failure rate and decrease the timeline for delivering new, important medicines to patients’ medicine cabinets.” Hudson said it currently takes about 15 years and more than $1 billion to develop a new drug and the failure rates are quite high at every step because of safety and because of efficacy.
“The new partnership effort is really targeted towards trying to boost the success of the pipeline by improving efficacy. What we’re exploring in this partnership is using a whole bunch of different new approaches and new technologies to try to identify higher quality targets that can enter the drug development pipeline,” said Hudson.
The private sector drug firms will match NIH dollars one-for–one. The other key contribution, according to Hudson, is that “industry scientists and NIH scientists and academic scientists all come at these problems with slightly different perspectives and experience and expertise, and by combining those together we’re really getting a research plan that is distinctive from what any one of us would have generated by ourselves.”
Hudson said another critical issue that is helping the collaboration is the fact that “the ground rules have been so clearly laid out about us working in a precompetitive space, about all of the data being broadly shared not just with the participants but with the entire scientific community.” Even with the collaboration, identifying and testing new compounds will take years. How to commercialize successful products will be part of the ongoing discussions.
>>Bonus Link: Read more about the Accelerated Medicines Partnership
CDC: American Indians, Alaska Natives Have 50 Percent Higher Death Rates than Non-Hispanic Whites
American Indian and Alaska Native (AI/AN) death rates were approximately 50 percent higher than rates among non-Hispanic whites—for both men and women—from 1999 to 2009, according to a new study in the American Journal of Public Health. The study determined that patterns of mortality were strongly influenced by the high incidence of diabetes, smoking prevalence, problem drinking and health-harming social determinants. Among the findings:
- Among AI/AN people, cancer is the leading cause of death followed by heart disease. Among other races, it is the opposite.
- Death rates from lung cancer have shown little improvement in AI/AN populations and AI/AN people have the highest prevalence of tobacco use
- Suicide rates were nearly 50 percent higher for AI/AN people
- Death rates from motor vehicle crashes, poisoning and falls were two times higher among AI/AN people
- Death rates were higher among AI/AN infants
“The Indian Health Service is grateful for this important research and encouraged about its potential to help guide efforts to improve health and wellness among American Indians and Alaska Natives,” said Yvette Roubideaux, MD, MPH, acting IHS director, in a release from the U.S. Centers for Disease Control and Prevention. “Having more accurate data along with our understanding of the contributing social factors can lead to more aggressive public health interventions that we know can make a difference.” Read more on health disparities.
FDA Proposes New Program to Help Patients With Unmet Tech Needs
The U.S. Food and Drug Administration (FDA) has proposed a new program designed to help treat or diagnose people with serious conditions, but whose needs aren’t met by current technology. The proposed Expedited Access Premarket Approval Application for Unmet Medical Needs for Life Threatening or Irreversibly Debilitating Diseases or Conditions (“Expedited Access PMA” or “EAP”) program would include earlier and more interactive engagement with FDA staff, with the goal of providing patients with earlier access to safe and effective medical equipment. “The program allows manufacturers to engage early and often with the agency,” said Jeffrey Shuren, MD, director of the FDA’s Center for Devices and Radiological Health. “We expect most devices that enter this program will be in the pre-clinical trial phase.” Read more on technology.
Study Links Internet Use, Lower Depression Rates in Older Americans
Older Americans who spend more time online are also less likely to suffer from depression, according to a new study in The Journals of Gerontology: Series B. Using data on 3,075 retired men and women who didn’t live in nursing homes gathered by the U.S. Health and Retirement Survey, researchers determined that the 30 percent who were Internet users also had a 33 percent lower probability of depression. "The largest impacts on depression were actually for those people who lived alone, so it's really suggesting that it's about connecting with others, eliminating isolation and loneliness," lead study author Shelia Cotton, according to Reuters. Read more on aging.
Study: Mean Devices Approved for Pediatric Use Never Tested on Kids
The majority of medical devices recently approved for pediatric use were never actually tested on kids, but rather only on people ages 18 and older, according to a new study in the journal Pediatrics. Researchers analyzed the clinical data used to get each device approved, finding that 11 of 25 examined devices were not tested on any patient age 21 and younger, and that only four had been tested on patients under the age of 18; three devices were specifically approved for patients under age 18, while the test were approved for people ages 18 to 21. "Children are not simply 'small adults,' and a device found to be safe and effective in adults may have a very different safety and effectiveness profile when used in a pediatric population," said Brigham and Women's Hospital and Harvard Medical School research fellow Thomas J. Hwang, one of the study’s authors, according to Reuters. "Without this data, it is difficult for clinicians and parents to make informed treatment decisions that weigh the risks and benefits of a particular treatment.” Read more on pediatrics.
Kaiser Report Examines Employer-Sponsored Retiree Health Benefits
A new report from the Kaiser Family Foundation on employer-sponsored retiree health benefits for pre-65 and Medicare-eligible retirees finds that the percentage of employers sponsoring retiree health coverage has declined, while employers that offer coverage are redesigning their plans almost annually in response to rising health care costs. The report, Retiree Health Benefits At the Crossroads, also examines the effect of recent legislation on retiree health coverage, such as the Medicare drug benefit and the Affordable Care Act. Read more on aging.
Study: Fewer Blood Transfusions Would Mean Fewer Infections
The increased use of blood transfusions in hospitals also leads to the increased risk of infection, according to a new study in the Journal of the American Medical Association. In a review of 21 randomized control trials, researchers from the University of Michigan School of Public Health determined that for every 38 patients considered for a red blood cell transfusion, the reduction of transfusions would mean one patient did not develop a serious infection, with the elderly undergoing hip and knee surgeries benefiting the most. “The fewer the red blood cell transfusions, the less likely hospitalized patients were to develop infections, “ says lead author Jeffrey M. Rohde, MD, assistant professor of internal medicine in the division of general medicine at the U-M Medical School, in a release. “This is most likely due to the patient’s immune system reacting to donor blood (known as transfusion-associated immunomodulation or TRIM). Transfusions may benefit patients with severe anemia or blood loss; however, for patients with higher red blood cell levels, the risks may outweigh the benefits.” Read more on prevention.
CDC: Reducing High-risk Antibiotic Prescriptions Could Also Reduce Deadly Infections
The most recent Vital Signs report from the U.S. Centers for Disease Control and Prevention (CDC) finds that if prescriptions of high-risk antibiotics in hospitals were reduced by just 30 percent, then there could be as many as 26 fewer cases of deadly diarrhea infections with Clostridium difficile. “Improving antibiotic prescribing can save today’s patients from deadly infections and protect lifesaving antibiotics for tomorrow’s patients,” said CDC Director Tom Frieden, MD, MPH. “Health care facilities are an important part of the solution to drug resistance and every hospital in the country should have a strong antibiotic stewardship program.” As part of its ongoing efforts to improve antibiotic prescribing, the CDC has release a checklist of seven core elements for hospitals:
- Leadership commitment: Dedicate the necessary human, financial, and IT resources.
- Accountability: Appoint a single leader responsible for program outcomes. Physicians have proven successful in this role.
- Drug expertise: Appoint a single pharmacist leader to support improved prescribing.
- Act: Take at least one prescribing improvement action, such as requiring reassessment of prescriptions within 48 hours to check drug choice, dose, and duration.
- Track: Monitor prescribing and antibiotic resistance patterns.
- Report: Regularly report prescribing and resistance information to clinicians.
- Educate: Offer education about antibiotic resistance and improving prescribing practices.
Read more on infectious diseases.
Poorer Women Most Likely to Be Caught in ‘Vicious’ Caregiving, Financial Well-being Cycle
Low-income women are at increased risk of finding themselves caught in a “vicious cycle” of parental caregiving and financial well-being, according to a new study in The Journals of Gerontology. While women of better financial means can afford additional caregiver assistance and better health care for aging parents, poorer women lack those options. "People who had less household income and less financial resources were more likely to take care of their parents so there is this cycle that they cannot get out of—they are poor, then taking care of parents, then being poor and taking care of their parents—there's this kind of cycle," said lead author Yeonjung Lee, a researcher and professor at the Faculty of Social Work at the University of Calgary in Alberta, Canada, according to Reuters. Read more on aging.
Young Skin Cancer Survivors at Heightened Risk for Other Cancers
Younger skin cancer survivors are at increased risk for additional cancer types later in life, according to a new study in the journal Cancer Epidemiology, Biomarkers & Prevention. A review of data of more than 500,000 people with a history of nonmelanoma skin cancer found that while all age groups were at heightened risk for melanoma and other types of cancers, the increase was especially significant for people under the age of 25, who were 23 times more likely to develop cancer than people who had never had nonmelanoma cancer. The risk was 3.5 times higher for nonmelanoma survivors ages 25-44, 1.74 times higher for those ages 45-59 and 1.32 times higher for those older than 60. The types of cancer they are at risk for include melanoma skin cancer, and cancers of the breast, colon, bladder, liver, lung, brain, prostate, stomach and pancreas. Read more on cancer.
FDA’s ‘The Real Cost’ Multimedia Campaign to Graphically Depict the Health Consequences of Smoking
The U.S. Food and Drug Administration (FDA) has launched a new national public education campaign combating youth tobacco use. “The Real Cost” multimedia campaign—with television, radio, print, online and out-of-home advertising—brings together vivid imagery and compelling facts to graphically depict the health consequences of smoking, such as tooth loss and skin damage. The new campaign, which will run in 200 U.S. markets for at least 12 months, targets the 10 million kids ages 12 to 17 who have never smoked, but are at risk, as well as kids who have experimented with smoking. “We know that early intervention is critical, with almost nine out of every ten regular adult smokers picking up their first cigarette by age 18,” said FDA Commissioner Margaret A. Hamburg, MD. Each day, more than 3,200 youth under ages and younger try their first cigarette and more than 700 become daily smokers. Read more on tobacco.
HHS Expands Patient Access to Lab Records
The U.S. Department of Health and Human Services (HHS) is expanding patient access to health records by allowing patients, or their designated “personal representative,” access complete test reports from laboratories. The final rule also eliminates the exception under the Health Insurance Portability and Accountability Act of 1996 Privacy Rule to a patient’s right to access protected health information when it is held by a CLIA-certified or CLIA-exempt laboratory. “The right to access personal health information is a cornerstone of the Health Insurance Portability and Accountability Act (HIPAA) Privacy Rule,” said HHS Secretary Kathleen Sebelius. “Information like lab results can empower patients to track their health progress, make decisions with their health care professionals, and adhere to important treatment plans.” Read more on access to health care.
Study: Climate Change Could Mean Significantly More Heat-related Summer Deaths
The combination of climate change and the growing elderly population could mean a dramatic increase in the number of heat-related summer deaths over the next decades, according to a new study in the Journal of Epidemiology and Community Health. Using data on weather patterns and death rates from 1993 to 2006, researchers at the London School of Hygiene and Tropical Medicine, and Public Health England, concluded that if no preventive measures are taken then the number of 2,000 annual heat-related deaths in England and Wales will climb 257 percent by the 2050s, while the number of 41,000 deaths related to cold will fall two percent. People ages 75 and older are at the greatest risk. Preventive measures could air conditioning, as well as more sustainable options such as shading and changes in building insulation and construction materials. Read more on the environment.
HHS: Guides, Tools to Improve Safe Use of EHRs
The U.S. Department of Health and Human Services (HHS) has released a new set of guides and interactive tools to assist health care providers in more safely using and managing electronic health information technology products, such as electronic health records (EHRs). The resources—which include checklists, practice worksheets and recommended practices to assess and optimize the safe use of EHRs—are available at HealthIT.gov. Each guide is available as an interactive online tool or a downloadable PDF. The new tools are part of HHS’s plan to implement its Health IT Patient Safety Action and Surveillance Plan, released last July. Read more on technology.
Traumatic Brain Injury Linked to Higher Risk of Early Death
Traumatic brain injury (TBI) is linked to a higher risk of premature death, according to a new study in the journal JAMA Psychiatry. Researchers from the University of Oxford, United Kingdom, analyzed the records of all patients born in 1954 or later in Sweden who were diagnosed with TBI from 1969 to 2009, finding an increased risk of dying among patients who survived six months after TBI compared to those without TBI, with the risk remaining for years afterward. In particular, the study found an increased risk of death from external causes such as suicide, injury and assault, also was higher. “Current clinical guidelines may need revision to reduce mortality risks beyond the first few months after injury and address high rates of psychiatric comorbidity and substance abuse,” wrote the study authors. Read more on mental health.
Heavy Drinking During Middle Age Can Cause Earlier Memory Loss in Men
Heavy drinking during middle age can bring on earlier deterioration of memory, attention and reasoning skills in men, according to a new study in the journal Neurology. Researchers studied data on 5,000 men and 2,000 women whose alcohol consumption was assessed three times over a 10-year period before also taking three tests of memory, attention and reasoning, with the first test happening at the average age of 56. They found that men who drank at least 2.5 servings of alcohol a day experienced mental declines between 1.5 and 6 years earlier than the other participants. "Heavy alcohol consumption is known to be detrimental for health, so the results were not surprising...they just add that [it's] also detrimental for the brain and the effects can be observed as [early] as 55 years old," said study author Severine Sabia, a research associate in the department of epidemiology and public health at University College London. Read more on alcohol.
HUD to Grant Millions in Rental Assistance for Senior Housing Developments
The U.S. Department of Housing and Urban Development (HUD) has announced $14.8 million to preserve affordable rental assistance for elderly tenants living in subsidized properties. This funding is provided through HUD’s Senior Preservation Rental Assistance Contracts and is targeted for properties in HUD’s “Supportive Housing for the Elderly” program, where rental assistance may expire without the new funding. Read more on aging.
U.S. Forest Service Will Waive Some Recreation Fees Five Times in 2014
The U.S. Forest Service will waive fees at most of its day-use recreation sites on: Jan. 20, 2014, in honor of Martin Luther King Jr. Day; President's Day weekend Feb. 15-17; National Get Outdoors Day on June 14; National Public Lands Day on Sept. 27; and Veterans Day weekend from Nov. 8 to 11.
Get Outdoors Days helps to raise awareness that nature encourages healthy, active outdoor fun. In addition to waiving fees, various Forest Service units participate in a variety of public events on agency lands and in nearby cities and towns. Public Lands Day is the nation's largest, single-day volunteer effort in support of public lands. Agency units plan their own events, which range from educational programs to trash pick-up to building trails.
National forests and grasslands include more than 150,000 miles of trails, which include hiking, biking, equestrian and motorized trails, and more than 10,000 developed recreation sites, as well as 57,000 miles of streams, 122 alpine ski areas, 338,000 heritage sites, 9,100 miles of National Scenic Byways, 22 National Recreation Areas, 11 National Scenic Areas, seven National Monuments, one national preserve and one national heritage area.
Many sites are already free; fees that could be waived under the program include picnic grounds and admission to visitor centers. Read more on physical activity.
Healthier Holiday Ideas from the USDA
As its holiday gift, the U.S. Department of Agriculture offers some healthy tweaks for consumers to help make holiday celebrations healthier including ideas for lighter cocktail fare, lower sugar and lower fat recipes for baked goods, and gift-giving ideas that focus on physical activity. Read more on obesity.
Study: Children, Teens Exposed to Far Too Many Alcohol Ads on Television
Children and teens continue to see too many television ads for beer, wine and other alcoholic drinks, with the industry failing to follow its own voluntary standard covering the number and frequency of ads, according to new research from the Johns Hopkins Bloomberg School of Public Health in Baltimore. The voluntary standards call for alcohol companies not to advertise during programs when more than 30 percent of the viewing audience is likely to be younger than 21. However, using data from 25 of the largest markets in 2010, the study found that nearly one in four of the alcohol ads on the most popular programs for viewers aged 12-20 violated the voluntary standards. Alcohol contributes to an estimated 4,700 deaths among underage youth in the United States each year, with studies showing that exposure to alcohol marketing increases the likelihood of underage drinking. "Underage drinking harms teens, their families and their communities," CDC Director Tom Frieden, MD. "Exposing teens to alcohol advertising undermines what parents and other concerned adults are doing to raise healthy kids." The findings appeared in the latest CDC Morbidity and Mortality Weekly Report. Read more on alcohol.
Kaiser Family: Most Americans Support Global Health Efforts, Although Don’t Fully Understand It
A new survey from the Kaiser Family Foundation finds that while the majority of Americans support the current U.S. efforts to improve public health in developing countries, there remain misconceptions about the levels of U.S. spending and how it is allocated. The 2013 Survey of Americans on the U.S. Role in Global Health was conducted in August 2013, through a random phone survey of 1,507 adults. According to the survey, 31 percent of Americans says we spend too little and 30 percent say we spend enough. However, the average American also believes foreign aid accounts for 28 percent of the federal budget, when in reality it is approximately 1 percent. Most people polled also don’t realize that most of the aid goes toward specific program areas, and is not simply a blank check to be allocated by the recipient country. Read more on global health.
About 10 Percent of Americans, 25 Percent of Adults Suffer from Arthritis
About 10 percent of Americans have arthritis, with half of them so severely affected that they can’t perform normal daily activities, according to the U.S. Centers for Disease Control and Prevention’s (CDC) Morbidity and Mortality Weekly Report. The report found that about 52.5 million adults—or about one quarter of all U.S. adults—had some form of arthritis; experts expect that number to climb to 57 million by 2030 as the population grows older. However, there are other possible explanations for the increasing problem. "The increase in arthritis definitely has to do with the aging of our population, but it's also potentially linked to the obesity epidemic," said the study's lead author, CDC epidemiologist Kamil Barbour. Read more on aging.
American Heart Association: Doctors Should Routinely Ask About Physical Activity
A new scientific statement from the American Heart Association says that doctors should evaluate their patients’ physical activity habits as routinely as checking blood pressure and other risk factors for cardiovascular diseases. The statement was published in the journal Circulation.
The statement says that an exercise checkup should cover types, frequency, duration and intensity of physical activity at work, home and during leisure time.
The American Heart Association recommends at least 30 minutes of moderate-intensity aerobic activity five days a week or more, or at least 20 minutes of vigorous aerobic activity three days a week or more and moderate- to high-intensity muscle strengthening at least two days a week. Read more on heart health.
People with Mental Health Problems More Likely to be Uninsured
A new University of Minnesota study published in Health Affairs finds that people with mental health problems are more likely to be uninsured and rely on public insurance than people without mental health problems. The study reviewed national insurance coverage rates from 1999 to 2010. The study authors say the implementation of the Affordable Care Act will give many more people with mental health problems access to health insurance – particularly in states such as Minnesota that have that have opted to expand their Medicaid programs. The researchers also say that people with mental health problems on public insurance have better access to care and lower cost barriers than the uninsured or those with private health insurance coverage.
Kathleen Rowan, the lead author of the study and a doctoral student in health services research, policy, and administration at the University of Minnesota School of Public, says, “unfortunately, most persons with mental illness do not receive needed care due in part to a lack of health insurance coverage and the cost of treatment.” Read more on mental health.
Study: Research to Delay Aging is a Better Investment Than Cancer, Heart Disease Research
A new study in current issue of Health Affairs finds that research to delay aging and the infirmities of old age would produce better health and economic returns than advances in some fatal diseases such as cancer or heart disease.
The study found that even modest gains in the scientific understanding of how to slow the aging process would result in an additional 5 percent of adults over the age of 65 remaining healthy rather than disabled every year from 2030 to 2060, or 11.7 million more healthy adults over age 65 remaining healthy by 2060.
The analysis was conducted by scientists from a consortium of research centers. “Even a marginal success in slowing aging is going to have a huge impact on health and quality of life. This is a fundamentally new approach to public health that would attack the underlying risk factors for all fatal and disabling diseases,” said S. Jay Olshansky, professor of epidemiology at the UIC School of Public Health and one of the study’s authors. “We need to begin the research now. We don’t know which mechanisms are going to work to actually delay aging, and there are probably a variety of ways this could be accomplished, but we need to decide now that this is worth pursuing.” Read more on aging.
Study: Majority of U.S. Medical Schools Still Lack Proper Clinical Conflict of Interest Policies
Despite recent efforts to improve policies, most U.S. medical schools still do not meet national standards regarding clinical conflicts of interest (CCOI), according to a new study from the Institute on Medicine as a Profession (IMAP). The study looked at changes in a dozen areas from 2008 to 2011, finding that by 2011 about two-thirds of the schools did not have policies to limit industry ties in at least one of the areas, such as drug samples, travel payments and speaking. No school was perfect across the board. "There has been a broad and rapid transformation in how academic medicine manages industry relationships since we looked at this in 2008, but much room for improvement remains," says co-author David Rothman, PhD, president of IMAP. To facilitate continued improvements, IMAP last launched a Conflict of Interest Policy Database that enables anyone to search a school's CCOI policies and compare them to other schools. "Our hope is that the database will encourage deans, compliance officers, faculty and students to compare their school with others and take steps to meet national recommendations," said IMAP investigator Susan Chimonas, PhD. Read more on education.
Online Tools Can Help Diagnose Mental Health Disorders
While it can’t replace in-person observations, an online diagnostic tool has proven to be effective at screening adults for mental health disorders and giving preliminary diagnoses, according to a new study in the journal Family Practice. The TelePsy eDiagnostics system is used in primary care practices in The Netherlands. Patients completed a questionnaire, which was then analyzed by a psychologist who would perform a phone consultation with the patient. The result would be a report submitted to a primary care provider, which would include a preliminary diagnosis and recommendations on whether the patient should be referred to mental health care, as well as the extent of the care. "The great advantage of an electronic system is that patients can complete diagnostic tests at home,” said lead author Ies Dijksman, according to Reuters. “This could lead to a more accurate information collection process compared to conventional clinical interviews.” However, experts were careful to note that in-person diagnostics meant physicians could also account for things such as visual cues, which could help improve diagnoses. Read more on mental health.
Study: No Reason for Healthy Adults to Take Vitamin D Supplements to Prevent Osteoporosis
Regular vitamin D supplements do not prevent osteoporosis in healthy adults who do not already suffer from a vitamin D deficiency, according to a new review publish in The Lancet. Researchers reviewed data from 23 studies covering more than 4,000 healthy adults with an average age of 59, finding no evidence that two years of supplements had an effect on bone mineral density at the hip, spine, forearm or the body as a whole. "The review supports previous studies that found that vitamin D alone is not preventative in healthy adults," said Victoria Richards, an assistant professor of medical sciences at the Netter School of Medicine at Quinnipiac University in Hamden, Conn. "From this study, consumers may no longer feel the need to continue purchasing vitamin D supplements for the prevention of osteoporosis.” Read more on aging.