Category Archives: Research
Flu Vaccine Reduces Risk of Child’s Flu-Related ICU Hospitalization by 74 Percent
Receiving a flu vaccine dramatically reduces a child’s risk of flu-related intensive care hospitalization, according to a new study in the Journal of Infectious Diseases. Researchers at the U.S. Centers for Disease Control and Prevention (CDC) analyzed the medical records of 216 children age 6 months through 17 years admitted to 21 pediatric intensive care units (PICUs) in the United States during the 2010-2011 and 2011-2012 flu seasons, finding that the a flu vaccination reduces the risk of being admitted to a PICU by 74 percent. “These study results underscore the importance of an annual flu vaccination, which can keep your child from ending up in the intensive care unit,” said Alicia Fry, MD, a medical officer in CDC’s Influenza Division. “It is extremely important that all children—especially children at high risk of flu complications—are protected from what can be a life-threatening illness." Kids younger than 5 and those with chronic medical conditions such as asthma, diabetes or developmental delays are at especially high risk of serious flu complications. Read more on influenza.
CDC Releases Expansive Salmonella Report for Researchers
The U.S. Centers for Disease Control and Prevention (CDC) has released an expansive, first-of-its kind report charting the past four decades of laboratory-confirmed surveillance data on 32 Salmonella serotypes. An Atlas of Salmonella in the United States, 1968-2011, includes data and analysis by age, sex, season and geography down to the county level. The report is available both online and in a downloadable format. Salmonella causes an estimated 1.2 million illnesses, 23,000 hospitalizations and 450 deaths each year in the United States. “We hope these data allow researchers and others to assess what has happened and to think more about how we can reduce Salmonella infections in the future,” said Robert Tauxe, MD, deputy director of CDC’s Division of Foodborne, Waterborne and Environmental Diseases. “The more we understand Salmonella, the more we can make progress in fighting it all along the farm to table chain.” Read more on research.
GlaxoSmithKline Recalling Alli Non-Prescription Weight-Loss Drug Amid Reports of Tampering
GlaxoSmithKline is working with the U.S. Food and Drug Administration in recalling all supplies of its non-prescription weight-loss drug Alli in the United States and Puerto Rico, after reports that some bottles had been tampered with and may not contain authentic Alli. The drug comes in a turquoise-blue capsule, but the company has received inquiries from consumers in seven U.S. states about bottles containing a range of tablets and capsules of various shapes and colors. Read more on safety.
A surprising piece of information at this week’s AcademyHealth National Health Policy Conference came during a session on what additional evidence is needed to move forward in the prevention and treatment of obesity. Linda Billheimer, PhD, deputy director of the health, retirement and long term analysis office at the Congressional Budget Office, said that one weakness of some obesity clinical trials is that they may not reflect the number of people who drop out during the trial. For example, while a study may show the success rate for 400 participants, it may not account for the number of people who left the trial and have not lost weight—or even gained weight—since their trial participation.
Billheimer noted that retaining patients can be difficult because people who plateau are often frustrated, which can combine with other reasons to lead them to leave.
Attempting to keep participants in the trial can be critical because the modality offered may be a strong opportunity for the participants to lose weight, since the trials often have novel approaches. There is also the support from the clinical trials team. Researchers at the session noted that trial funders might add criteria to the trial on follow up for participants who withdraw to possibly increase participation time among a larger group of patients.
Recent novel obesity trials listed by the U.S. National Institutes of Health on ClinicalTrials.gov include
- A trial comparing low and high financial incentives for weight loss
- Using virtual reality to help trial participants work on weight loss
- Community based obesity prevention among black women
PSA Campaigns Uses Pets to Remind Uninsured People of Deadline to Enroll Under the ACA
With research showing that more than 80 percent of Americans are unaware of the March 31 deadline to sign up for health coverage under the Affordable Care Act, Enroll America has partnered with the Ad Council on the launch of a new national campaign to raise awareness, educate and motivate people to enroll. The “Take Care, People” national multimedia public service advertising (PSA) campaign, which is focuses on women ages 18-34, took a somewhat unusual approach when it came to selecting spokespeople: pets. “We needed a familiar face that would stand out amidst all the noise to communicate to all Americans the benefits of enrolling for health insurance in a way that’s entertaining, relatable and easy to digest,” said Creative Director Rodrigo Butori of La Comunidad, which created the PSAs along with Razorfish. “We thought about pets. Why? Two thirds of American homes have pets. They have been the recipient of people’s love and care for ages. So it’s time for them to return the favor. It’s time for pets to take care of people for a change.” Read more on the Affordable Care Act.
PHLR Online Database Brings Together Experts and Peer-reviewed Publications
Public Health Law Research (PHLR), a program of the Robert Wood Johnson Foundation, has launched the new PHLR SciVal Expert Community to allow users to discover existing and emerging evidence on laws and legal practices that improve health, to identify experts in the area and to pursue new collaborations. The searchable database currently includes 240 expert public health law researchers and more than 16,000 of their peer-reviewed publications covering a range of topics, from alcohol, tobacco and other drugs to occupational safety and health, oral health and preparedness. Read more on research.
Study: Healthy Eating on Weekdays the Key to Losing Weight
The key to losing weight and keeping it off may be healthier eating on weekdays rather than weekends, according to a new study in the journal Obesity Facts. Knowing that most people tend to gradually lose weight during the week and then gain it back on the weekends, researchers tracked the eating habits of 80 people ages 25 to 62, having them weigh themselves before breakfast every day for anywhere from two weeks to nearly a year. The study found that everyone experienced weight fluctuations, but that the people who consistently lost weight tended to compensate more strictly during the week for their weekend weight gain, with their weight decreasing immediately on Monday and continuing downward until Friday. "The ones who are big winners are those who lose a little bit of weight from Monday to Tuesday to Wednesday to Thursday," said study co-author Brian Wansink, a professor of consumer behavior at Cornell University. Read more on obesity.
Recommended Reading: ‘Retweet This’—Researchers See Rise in Use of Twitter to Share Scientific Journal Articles
The top two tweeted peer-reviewed science articles between 2010 and 2012 were about the effect of radiation on humans, according to a study published in the Journal of the Association for Information Science and Technology. Researchers reviewed 1.4 million articles to determine the most tweeted studies. Runners up in the top 15 of the most tweeted articles included studies on acne in teenagers and the link between physical activity and mortality rates. Nature, a highly regarded journal, received the most tweets: 13,430 Twitter mentions of 1,083 papers.
However, the researchers found that a retweet rate doesn’t necessarily correlate with a high rate of citations for an article in other studies, which is a standard measurement of significance for a scientific study. The most tweeted study—on genetic changes during radiation exposure—was tweeted 963 times but was cited in journals only nine times.
"The most popular scientific articles on Twitter stress health implications or have a humorous or surprising component. This suggests that articles having the broadest scientific impact do not have the widest distribution," said Stefanie Haustein, of the University of Montreal School of Library and Information Science, and a co-author of the study.
Still, the researchers say the increase in tweets that include a link or description of scientific studies is important even if the rates don’t correlate with journal citations. For one thing, the number of scientific researchers on Twitter is still low and “the fact that more and more articles are tweeted [at all] is good news because it helps scientific communication [and] regardless of whether non-scientists are sending this information, it proves that science is an aspect of general culture,” said Vincent Larivière, PHD, a co-author of the study and professor at the University of Montreal, who holds the Canada Research Chair on the Transformation of Academic Communication.
Read the full study.
HHS: $8M in Research Grants to Support Hurricane Sandy Recovery
The U.S. Department of Health and Human Services (HHS) has awarded more than $8 million in research grants to support the long-term recovery of areas of the country damaged by Hurricane Sandy in late 2012. The grants, which are part of the Hurricane Sandy Recovery and Rebuilding Supplemental Appropriation Act of 2013, will go toward research on issues such as community resilience; risk communications and the use of social media; health system response and health care access; evacuation and policy decision making; and mental health. “We hope the grants provide a catalyst for the scientific community to put more emphasis on the study of recovery from disasters; much more research is needed to support decision making in the long-term recovery process and ultimately to improve resilience,” said Nicole Lurie, MD, HHS assistant secretary for preparedness and response. “We anticipate that the findings not only will help community leaders make evidence-based decisions about recovery plans and policies in affected areas but also that the knowledge gained can improve resilience across the entire country.” Read more on disasters.
NIH, CDC Launch National Registry on Sudden Deaths in the Young
The U.S. National Institutes of Health (NIH) and the U.S. Centers of Disease Control and Prevention have come together in the launch of the Sudden Death in the Young Registry. The registry will catalogue conditions such as heart disease and epilepsy in order to help researchers better understand the issues and establish future research priorities. According to the NIH, up until now there have not been agreed upon standards or definitions for reporting these deaths, which has impeded efforts to determine the best prevention efforts. "The sudden death of a child is tragic and the impact on families and society is incalculable," said Jonathan Kaltman, MD, chief of the Heart Development and Structural Diseases Branch within the Division of Cardiovascular Sciences at the NIH's National Heart, Lung, and Blood Institute. "This registry will collect comprehensive, population-based information on sudden unexpected death in youths up to age 24 in the United States. It is a critical first step toward figuring out how to best prevent these tragedies." Read more on research.
Mother’s Smoking During Pregnancy Increases Infant’s Risk of Infections, Death
Mothers who smoked during pregnancy are more likely to have children who are at increased risk for hospitalization and death during infancy, according to a new study in the journal Pediatric Infectious Diseases. The study analyzed hospital records and death certificates of approximately 50,000 Washington state infants born between 1987 and 2004. Researchers say a weakening of the child’s immune system may be responsible for the heightened risk. "We've known for a long time that babies born to mothers who smoke during pregnancy are at high risk for serious medical problems relating to low birth weight, premature delivery and poor lung development," said lead author Abigail Halperin, MD. "While respiratory infections have been recognized as a common cause of these sometimes life-threatening illnesses, this study shows that babies exposed to smoke in utero [in the womb] also have increased risk for hospitalization and death from a much broader range of infections—both respiratory and nonrespiratory—than we knew before.” Read more on tobacco.
CDC Flu Reports to Resume Later Today
The U.S. Centers for Disease Control and Prevention (CDC) reported late yesterday that it has resumed analysis of influenza surveillance data and testing of influenza laboratory specimens collected during the 16-day government shut-down. An abbreviated FluView report summarizing the data for the most recent week (October 6-12) will be posted on Friday, October 18. At a later date, reports summarizing influenza surveillance data for September 22-October 5 will also be posted. Weekly Friday posting of the full FluView report for the 2013-2014 season will begin again on October 25. In the United States, flu season typically runs September through April and both private doctors and public health clinics currently have large supplies of this year’s flu vaccine on hand. Find a flu shot in your neighborhood by using the Health Map Vaccine Finder, run by Boston Children’s Hospital. Read more on flu.
Brain May Flush Out Toxins During Sleep
A new study funded by the U.S. National Institutes of Health finds that a good night’s rest may literally clear the mind. The study, conducted in mice, showed—for the first time, according to the researchers—that the space between brain cells may increase during sleep, allowing the brain to flush out toxins that build up during waking hours. The researchers say that suggests a new role for sleep in health and disease. The study, published in Science, shows that during sleep a plumbing system called the glymphatic system may open, letting fluid flow rapidly through the brain. The researchers studied the system by injecting dye into the cerebrospinal fluid of mice and watching it flow through their brains while simultaneously monitoring electrical brain activity. The dye flowed rapidly when the mice were either asleep or anesthetized, but barely flowed when the same mice were awake. The researchers also inserted electrodes into the brains of the mice to directly measure the space between brain cells and found it increased by 60 percent when the mice were asleep or anesthetized. Researchers say the applications may apply to general health as well as have implications for neurological disorders. Read more on research.
New Report Offers Suggestions for Creating Healthier Neighborhoods
Again and again, research shows that our environment—where we live and what behaviors it fosters—has a profound impact on our health. Realizing this, a new report from the Prevention Institute offers interviews with fifty leaders in multiple sectors, including transportation, housing and public health on how to create healthy, safe and equitable neighborhoods. The goal of the report, Towards a 21st Century Approach: Advancing a Vision of Prevention and Public Health, is to spark an active and ongoing national dialogue about the subject. It was made possible through funding from the Robert Wood Johnson Foundation. Read more on smart growth.
Average Monthly Cost of Mid-tier Insurance Under Affordable Care Act Estimated at $328
The average monthly cost of a mid-tier health insurance plan under the Affordable Care Act will be $328, and government subsidies will also help reduce that cost for most Americans, according to a new report from the U.S. Department of Health and Human Services. The health exchanges open for enrollment next week and the federal government hopes to enroll as many as 7 million people within the first year. The cost varies from state to state, with Minnesota projected to have the least expensive plan at $192 per month and Wyoming projected to have the highest at $516. Read more on access to health care.
NIH Initiative Will Help Move Science from the Laboratories to the Commercial Sector
The U.S. National Institutes of Health (NIH) has awarded $31.5 million in grants to establish three inaugural NIH Centers for Accelerated Innovations that will work to improve how basic science discoveries move from laboratories to commercial products. The Centers are funded by NIH’s National Heart, Lung and Blood Institute (NHLBI) and will focus on technologies to improve the diagnosis, treatment, management and prevention of heart, lung, blood and sleep disorders and diseases. “These centers essentially will offer a one-stop shop to accelerate the translation of early-stage technologies for further development by the private sector and ultimate commercialization,” said Gary H. Gibbons, MD, director of NHLBI. As a result, the public will gain access sooner to new biomedical products that improve human health while also benefiting from the economic growth associated with the creation of new companies and the expansion of existing ones.” Read more on research.
‘Cycling’ Drugs Could Help Combat Antibiotic-resistant Bacteria
“Cycling” between antibiotics may extend their life and effectiveness, while also enabling doctors to stay ahead of drug-resistant bacteria, according to a new study in the journal Science Translational Medicine. "You cycle between drugs that have reciprocal sensitivities," said study co-author Morten Sommer, a lead researcher with the Novo Nordisk Foundation Center for Biosustainability at the Technical University of Denmark. "If you become resistant to drug A, you will become more sensitive to drug B. That way, you can cycle between drug A and drug B without increasing resistance in the long term.” With the increased use—and overuse—of antibiotics, antibiotic-resistant bacteria are becoming an increasingly serious public health problem, leading researchers and health care professionals in search of new ways to combat the problem. More than 2 million people are made ill and more than 23,000 people die every year in the United States due to antibiotic-resistant infections, according to the U.S. Centers for Disease Control and Prevention. Read more on prescription drugs.
Study: 40 Percent of Antibiotics Released from 1980-2009 Withdrawn from Market
Safety concerns, lack of effectiveness when compared to existing drugs and weak sales led more than 40 percent of the antibiotics released between 1980 and 2009 to be withdrawn from the market, according to a new study in the Journal of Law, Medicine and Ethics. The rate was three times as high as that for any other type of drug. “This study raises the question whether or not money would be better spent on higher quality antibiotics, rather than a larger quantity” and whether “approving a flood of new lower-quality antibiotics might actually trigger much higher levels of resistance,” said author Kevin Outterson, JD, LLM, professor at Boston University School of Law and co-director of the Boston University Health Law Program. Antibiotic use can lead to bacteria becoming resistant to a strain. A recent report from the U.S. Centers for Disease Control and Prevention found that as many as 50 percent of prescriptions for antibiotics are either not needed or prescribed inappropriately. Antibiotic-resistant infections sicken more than two million Americans each year, killing more than 23,000 in the process. Read more on prescription drugs.
Locations of Drinking Can Influence Types of Partner Violence
Where and when a person drinks can affect the type of partner violence that can follow, according to a new study from the journal Addiction. The study looked at six drinking locations: restaurants, bars, parties at someone else's home, quiet evenings at home, with friends in one's own home and in parks/other public places. Researchers from the Prevention Research Center in California and Arizona State University found that men drinking in bars and at partners away from home and women drinking in parks/other public places were linked with an increased rate of male-to-female violence. They also found that men drinking during quiet evenings at home was associated with increased female-to-male violence. The findings could help prevent partner violence by encouraging people in risky relationships not to drink in particular places/situations, which could prove more effective than counseling people simply to drink less. Read more on alcohol.
Multiple Myeloma Group Hopes Opening Records to Hundreds of Patients Will Advance Research
The Multiple Myeloma Research Foundation's (MMRF) Researcher Gateway is opening global online access to genetic and research data on hundreds of patients in an effort to help identify biological targets for future treatments, improve enrollment in studies by pairing them with the right patients and enhance researcher collaboration. The MMRF Research Gateway is a $40-million program funding by the foundation and drug company partners. The main component of the effort will be the Commpass study which will enroll 1,000 new multiple myeloma patients and monitor them throughout the course of the disease; cancer tissue banks typically include only one sample per patient. "There is going to be new information generated there that you would never get unless you followed patients through first relapse and second relapse and beyond," said George Mulligan, director of translational medicine for Millennium Pharmaceuticals, Japan's Takeda Pharmaceutical Co.’s oncology unit, which is one of the co-sponsors. "The size of it in patient numbers and the breadth and richness of it on a biological level, it's going to grow over time and mushroom into something that's going to be really special.” About 86,000 people are diagnosed with multiple myeloma each year, with about 20,000 of those from the United States. Read more on research.
CDC: ‘Tips From Former Smokers’ Campaign Created Spikes in Quitline Calls, Website Visits
An additional 150,000 U.S. smokers called the tobacco cessation helpline 1-800-QUIT NOW as a direct result of the U.S. Centers for Disease Control and Prevention's (CDC) 2013 “Tips From Former Smokers” campaign, which ran for 16 weeks, according to CDC’s latest Morbidity and Mortality Weekly Report. That’s an increase of about 75 percent. It also generated approximately 2.8 million visits to the campaign website, or a nearly 38-fold increase. "The TIPS campaign continues to be a huge success, saving tens of thousands of lives and millions of dollars; I wish we had the resources to run it all year long," said CDC Director Tom Frieden, MD, MPH. "Most Americans who have ever smoked have already quit, and most people who still smoke want to quit. If you smoke, quitting is the single most important thing you can do for your health – and you can succeed!" A recent study in The Lancet concluded that the campaign helped as many as 100,000 people quit smoking permanently. Read more on tobacco.
FDA, NIH Award as Much as $53M for 14 Tobacco Regulation Research Centers
The U.S. Food and Drug Administration (FDA) and the National Institutes of Health (NIH) have joined together to award as much as $53 million in funding to create 14 Tobacco Centers of Regulatory Science (TCORS). The first-of-its-kind program will bring together a diverse array of scientists, public health experts, communications veterans and marketing experts to generate research to inform the regulation of tobacco products to protect public health. “While we’ve made tremendous strides in reducing the use of tobacco products in the U.S., smoking still accounts for one in five deaths each year, which is far too many,” said NIH Director Francis S. Collins, MD, PhD. “FDA/NIH partnerships like the Tobacco Centers of Regulatory Science keep us focused on reducing the burden and devastation of preventable disease caused by tobacco use.” Read more on research.
Overweight, Underweight Pregnant Women See More Complications and Longer Hospital Stays
Pregnant women who are either too thing or too heavy as measured by body-mass index (BMI) are at increased risk for complications and additional hospitalization, according to a new study in BJOG: An International Journal of Obstetrics and Gynaecology. Women with higher BMIs saw increased complications; severely obese women were three times as likely as normal weight women to have high blood pressure and gestational diabetes, as well as longer overall hospitalizations. Lower-weight women also had higher rates of additional hospitalization (8 percent) compared to normal-weight women, though not as high as the rates for overweight and obese women. The findings indicate the need to fine and implement new approaches to combating obesity. "Longer-term benefits of reducing maternal obesity will show improvements, not only in the health outcomes of mothers and their babies, but the workload and cost to current maternity services," said study co-author Fiona Denison, MD, of Queens's Medical Research Institute in Edinburgh. Read more on maternal and infant health.
Critical Opportunities: New Journal Article, Videos Offer Proposed Legal and Policy Changes that Can Impact Public Health
Ten new videos released today by Public Health Law Research (PHLR), a national program of the Robert Wood Johnson Foundation, with direction and technical assistance from Temple University, offer suggestions of proposed changes to laws and policies that can impact public health, such as fortifying corn masa flour to prevent neural tube defects and increasing taxes on alcohol to reduce consumption. The five-minute videos offer examples of PHLR’s “Critical Opportunities” initiative—brief presentations which showcase legal approaches to improving public health.
“Laws can be cost-efficient and popular tools for achieving public health goals. This initiative captures specific actionable, evidence-based ideas for creative ways of using law or legal interventions to improve a public health problem,” said Scott Burris, JD, director of the PHLR program.
The release of the videos is accompanied by an article published this week in the American Journal of Public Health, “Critical Opportunities for Public Health Law: A Call to Action.” It outlines five high-priority areas where evidence suggests legal interventions can have big impacts on health, and calls for a national conversation to continue to identify and prioritize opportunities for legal and policy action.
“The Centers for Disease Control and Prevention, the Institute of Medicine, and others have called for better, smarter use of legal interventions to advance public health,” said Michelle Mello, JD, PhD, the lead author of the article and professor of law and public health at Harvard University. “That’s no small task, but there’s a treasure trove of great ideas to draw on and evidence to back them up.”
PHLR has also developed a toolkit for use by organizations or instructors to host Critical Opportunities sessions at their meetings or in classrooms. The toolkit offers a how-to guide for using the format to identify ways laws can be used to address public health issues.
All ten of the new Critical Opportunities videos are available here. To highlight just one of the presentations, NewPublicHealth recently spoke with Adam Finkel, ScD, of the University of Pennsylvania Law School, about his Critical Opportunity presentation on the benefit and limitations of “smart disclosures,” an alternative to regulations and laws for improving public health.